Circular Regulating the List of Congenital Diseases to be Screened Prenatally and Neonatally 12/2026/TT-BYT

✦ 智能摘要

This Circular by the Ministry of Health regulates the list of congenital diseases that are encouraged for screening during both prenatal and neonatal periods. The list includes various types of diseases such as metabolic disorders, genetic diseases, congenital malformations... in order to detect early so as to take timely intervention measures.

适用范围

Healthcare facilities and organizations related to medical treatment and screening of congenital diseases in Vietnam.

要点

The list of congenital diseases encouraged for prenatal screening includes 70 types of diseases.
The list of congenital diseases encouraged for neonatal screening includes 33 types of diseases.
The method of dried blood spot (DBS) sampling is used in some cases for neonatal screening.
To detect early the presence of congenital diseases so as to take timely intervention measures, thereby minimizing the consequences for children and their families.
This Circular will help improve the quality of medical treatment and child health care services for mothers and children in Vietnam.

🌐 本文件的社会影响

To detect early dangerous congenital diseases, thus taking timely intervention measures.
To raise community awareness of the importance of prenatal and postnatal screening.
To strengthen the healthcare system to implement medical treatment and child health care services for mothers and children.

❓ 常见问题

Does this list include congenital malformations?

Yes, the list includes various types of congenital malformations, including those affecting the circulatory system and other types of malformations.

In which cases is the dried blood spot sampling method used?

This method is primarily used for neonatal screening to detect metabolic disorders, genetic diseases...

全文

MINISTRY OF HEALTH

No.: /2026/TT-BYT

THE SOCIALIST REPUBLIC OF VIET NAM

Independence - Freedom - Happiness

Hanoi, May 5, 2026

CIRCULAR

Regulating the List of Prenatal and Neonatal Screening Recommended Congenital Diseases

BASED ON THE POPULATION LAW No. 113/2025/QH15;

BASED ON THE MEDICAL EXAMINATION AND TREATMENT LAW No. 15/2023/QH15;

BASED ON DECREE No. 42/2025/NĐ-CP dated February 27, 2025 of the Government on the Functions, Powers, Tasks, and Organizational Structure of the Ministry of Health;

IN ACCORDANCE WITH THE RECOMMENDATION OF THE DIRECTOR OF THE POPULATION SECTION;

THE MINISTER OF HEALTH ISSUES THIS CIRCULAR TO REGULATE THE LIST OF PREGNANCY AND NEONATAL SCREENING RECOMMENDED CONGENITAL DISEASES.

Article 1. List of Congenital Diseases Recommended for Prenatal and Neonatal Screening

The list of congenital diseases recommended for prenatal screening, as specified in Appendix I, and the list of congenital diseases recommended for neonatal screening, as specified in Appendix II, are annexed to this Circular to provide detailed provisions under Clause 1 of Article 21 of the Population Law.

Article 2. Interpretation of Terms

A congenital disease is any structural or functional abnormalities (including metabolic disorders) occurring during fetal development and causing adverse effects on an individual's health.

Article 3. Principles for Formulating the List of Congenital Diseases

The selection of congenital diseases to be included in the list must ensure compliance with the following principles:

1. Prevalence and Burden of Disease:

a) Congenital diseases that have a high prevalence or carry a high risk of genetic mutation within the community, or cause severe health, physical, and intellectual consequences for children;

b) Congenital diseases that result in high mortality rates among children or lead to lifelong disabilities, affecting the quality of the human race.

2. Screening and Diagnostic Capabilities:

a) There are appropriate, safe, and easily implementable screening methods;

b) There are diagnostic methods or techniques available to confirm the disease status after screening results.

3. Feasibility and Economic-Social Efficiency:

a) Compliant with the equipment and human resource capacity of the Vietnamese healthcare system;

b) Screening costs are appropriate for the ability to pay of individuals or the national budget or health insurance;

c) The economic-social benefits gained from early detection, treatment, and intervention outweigh those obtained from late detection.

Article 4. Implementation

This Circular comes into effect on July 1, 2026.

Article 5. Organization of Implementation

1. Population Section:

a) Shall coordinate with relevant units to guide, direct, and inspect the implementation of this Circular nationwide;

b) Shall review and propose revisions or supplements to the list every two years or when there are professional, technical, or legal requirements, in coordination with the Population Section;

c) Shall work with the Mother and Child Section, the Medical Examination and Treatment Management Section, and relevant units to develop, update, and submit for approval procedures and guidelines on prenatal and neonatal screening, diagnosis, and treatment according to the provisions of the Medical Examination and Treatment Law;

d) Shall publish the list of congenital diseases recommended for prenatal and neonatal screening on the Population Section's website and the Ministry of Health's portal.

2. Mother and Child Section shall work with the Population Section, the Medical Examination and Treatment Management Section, and relevant units to develop, update, and submit for approval procedures and guidelines on prenatal and neonatal screening, diagnosis, and treatment according to the provisions of the Medical Examination and Treatment Law.

3. Medical Examination and Treatment Management Section shall work with the Population Section, the Mother and Child Section, and relevant units to develop, update, and submit for approval procedures and guidelines on prenatal and neonatal screening, diagnosis, and treatment according to the provisions of the Medical Examination and Treatment Law.

4. Provincial Health Authorities:

a) Shall direct and organize the implementation of this Circular;

b) Shall direct or review, advise relevant authorities to invest in infrastructure, equipment, and human resources for healthcare facilities under their management to ensure sufficient capacity for prenatal and neonatal screening;

c) Shall intensify information and communication efforts to inform the public about the importance of prenatal and neonatal congenital disease screening.

5. Healthcare Facilities:

a) Shall implement prenatal and neonatal screening, diagnosis, and treatment in accordance with the professional procedures issued by the Ministry of Health. Diagnosis and treatment for congenital diseases shall be conducted according to the provisions of the Medical Examination and Treatment Law;

b) Regional Screening Centers shall perform their assigned tasks and take responsibility for provinces and cities as designated by the Minister of Health.

">In case of difficulties or obstacles, entities may report to the Ministry of Health (Population Section) for guidance and resolution./.

To:

- Central Committee of the Communist Party of Vietnam;

- Prime Minister, Deputy Prime Ministers of the Government;

- Ministries, agencies at ministerial level, and subordinate bodies under the Government;

- People's Councils and People's Committees of provinces and centrally-administered cities;

- Central Party Committee offices and committees;

- Office of the General Secretary;

- Office of the President;

- Ethnic Affairs Committee and other National Assembly Committees;

- Office of the National Assembly;

- Supreme People's Court;

- Supreme People's Procuratorate;

- Audit Agency;

- Social Policy Bank;

- Vietnam Investment Bank;

- Central Committee of the Vietnamese Fatherland Front;

- Central offices of political and social organizations;

- Minister of Health (for record);

- Deputy Ministers of Health (for coordination and guidance);

- Provincial People's Committees of provinces and centrally-administered cities;

- Departments, Sections, Offices under the Ministry of Health;

- Office of the Government: Gazette; Portal of the Government;

- Portal of the Ministry of Health;

- Population Section offices in provinces and centrally-administered cities;

- VT, CDS, PC.

KT. MINISTER OF HEALTH

DEPUTY MINISTERS

DO XUAN TUYEN

MINISTRY OF HEALTH

THE SOCIALIST REPUBLIC OF VIET NAM

Independence - Freedom - Happiness

Appendix I

LIST OF RECOMMENDED CONGENITAL DISEASES FOR PREGNANCY AND NEONATAL SCREENING

(Annexed to Circular No. /2026/TT-BYT dated May 5, 2026 of the Minister of Health)

STT

ICD-10	Disease Name	Group I
Common Chromosomal and Genetic Diseases Requiring Prenatal Screening	D56
1	Thalassemia [Congenital Anemia]	Q90.0
2	Q90.0	Triploid chromosomal abnormality, failure to segregate during meiosis
3	Q91.0	Triploid chromosomal abnormality 18, failure to segregate during meiosis
4	Q91.4	Triploid chromosomal abnormality 13, failure to segregate during meiosis
5	Q96.0	Chromosome formula 45,X
6	Q98.0	Klinefelter syndrome with chromosome formula 47,XXY
7	Q90-Q99	Chromosomal abnormalities, not classified elsewhere
Group II	Structural fetal anomalies requiring prenatal screening are common
8	Q00.0	Anencephaly
9	Q01	Hydrocephalus ex vacuo
10	Q03	Congenital hydrocephalus
11	Q04.2	Total anterior encephalocele
12	Q05	Spina bifida occulta, with or without sacral dimple and/or tuft of hair
13	Q07.0	Chiari malformation I
14	Q11.1	Other congenital eye anomalies
15	Q20-Q28	Congenital cardiovascular defects
16	Q33.3	Pulmonary agenesis or hypoplasia
17	Q35	Cleft lip and palate
18	Q36	Cleft lip with cleft palate
19	Q37	Cleft lip and palate
20	Q39	Congenital esophageal atresia or stenosis
21	Q41.0	Congenital duodenal atresia, stenosis, or hypoplasia
22	Q60.1	Congenital jejunal atresia, stenosis, or hypoplasia
23	Q62.0	Bilateral renal agenesis
24	Q64.2	Congenital obstructive uropathy
25	Congenital urethral valves after birth	Clubfoot or other congenital foot deformities
26	Q69	Polydactyly
27	Syndactyly	Congenital upper limb deficiency
28	Congenital lower limb deficiency	Congenital hip dislocation or dysplasia
29	Q72	Congenital contractures of multiple joints
30	Q75.0	Craniosynostosis
31	Q77.1	Short stature due to skeletal dysplasias [dwarfism]
32	Q77.4	Achondroplasia, a form of short stature
33	Q78.0	Osteogenesis imperfecta
34	Q79.0	Congenital diaphragmatic hernia
35	Q79.2	Congenital intracranial herniation through the foramen ovale
36	Q79.3	Congenital visceral exenteration [through a periumbilical defect]
37	Group III	Prenatal screening is recommended for chromosomal and genetic disorders with family history
38	D57	Sickle cell anemia
D58.2	Other hereditary hemolytic anemias
39	D66	Hemophilia A due to factor VIII deficiency
40	D67	Hemophilia B due to factor IX deficiency
41	E25.0	Congenital adrenal hyperplasia related to enzyme deficiency
42	E70.0	Classic phenylketonuria
43	E70.2	Tyrosinemia
44	E71.0	Maple syrup urine disease
45	E71.1	Other organic acid metabolism disorders
46	E71.2	Organic acid metabolism disorder, not otherwise specified
47	E71.3	Fatty acid oxidation disorders
48	E72.1	Sulfur-containing amino acid metabolism disorders
49	E72.2	Urea cycle disorders
50	E72.3	Lysine and hydroxylysine metabolism disorders
51	E72.4	Ornithine metabolism disorders
52	E72.5	Glycine metabolism disorders
53	E74.0	Glycogen storage disease
54	E74.2	Galactosemia
55	E74.4	Pyruvate and/or glucose metabolism disorders
56	E75.0	GM2 gangliosidosis
57	E75.2	Other sphingolipidoses
58	E76.0	Mucopolysaccharidosis type I (MPS I)
59	E76.1	Mucopolysaccharidosis type II (MPS II)
60	E84	Scleroderma
61	G12.0	Infantile spinal muscular atrophy, type I [Werdnig-Hoffman]
62	G12.1	Other hereditary spinal muscular atrophies
63	G71.0	Myotonic dystrophy
64	Q61.2	Autosomal dominant polycystic kidney disease
65	Q85.0	Benign neurofibromatosis (non-malignant)
66	Q85.1	Sclerodermatous conditions
67	Q87.4	Marfan syndrome
68	Q99.2	Fragile X chromosome
69	Ministry of Health	Socialist Republic of Vietnam
70	Independence - Freedom - Happiness	Appendix II

LIST OF CONGENITAL DISORDERS RECOMMENDED FOR SCREENING

NEWBORN SCREENING EXAMINATION

(Accompanying Circular No. /2026/TT-BYT dated May 5, 2026 of the Minister of Health)

A. Congenital disorders recommended for screening without using dried blood spots on filter paper

STT

ICD-10 Code

Name of Disorder

H90

Sensorineural and/or conductive hearing loss	H91	Other hearing disorders
1	Q20-Q28	Congenital cardiovascular defects
2	B. List of congenital disorders recommended for screening using dried blood spots on filter paper	STT
3	ICD-10 Code	Name of Disorder

I. Basic congenital disorders recommended for newborn screening E03.0

Congenital hypothyroidism with goiter	E03.1	Congenital hypothyroidism without goiter
E03.8
1	Other congenital hypothyroidism	E25.0
2	Congenital adrenal hyperplasia due to enzyme deficiency	D55.0
3	Hemolytic anemia due to glucose-6-phosphate dehydrogenase (G6PD) deficiency	II. Amino acid metabolism disorders
4	E70.0	Classic phenylketonuria
5	E70.1	Other hyperphenylalaninemia E71.0
Maple syrup urine disease
6	E70.2	Tyrosinemia
7	E72.1	Sulfur-containing amino acid metabolism disorders
8	III. Organic acid metabolism disorders	E71
9	Amino acid metabolic disorders, including branched-chain and/or fatty acid oxidation disorders	E71.1
10	Other branched-chain amino acid metabolic disorders	E72.3
Lysine and hydroxylysine metabolism disorders
11	E53.8	Other vitamin B deficiency
12	E72.8	Other amino acid metabolic disorders
13	IV. Fatty acid oxidation disorders	E71.3
14	Fatty acid oxidation disorders	V.
15	Urea cycle disorders	E72.2
Urea cycle disorder
16	VI. Glycogen storage disease	E74.0
Glycogen storage disease VII. Other genetic disorders
17	E75.2	Galactosemia
18	G12.0	Infantile spinal muscular atrophy, type I [Werdnig-Hoffman]
G12.1
19	Other hereditary spinal muscular atrophies	E84
20	Scleroderma	D81.0
21	Severe combined immunodeficiency with lattice degeneration	D81.1
22	Severe combined immunodeficiency with low T and B cell counts	D81.2
Severe combined immunodeficiency with normal or low B cell count
23	D56	Thalassemia [sickle cell anemia]
24	D57	Sickle cell disease
25	D58.2	Other hemolytic anemias
26	G71.0	Myotonic dystrophy
27	D81.0	Combined Severe Immunodeficiency [SCID] with Lymphohistiocytosis
28	D81.1	Combined Severe Immunodeficiency [SCID] with Low T and B Cell Counts
29	D81.2	Combined Severe Immunodeficiency [SCID] with Low or Normal B Cell Count
30	D56	Thalassemia [Congenital Hemolytic Anemia]
31	D57	Sickle Cell Dyserythroid Condition
32	D58.2	Other Hemoglobinopathy
33	G71.0	Myopathic Disorder

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Circular Regulating the List of Congenital Diseases to be Screened Prenatally and Neonatally

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Tiếng Việt Thông tư Quy định Danh mục bệnh bẩm sinh cần sàng lọc trước sinh và sơ sinh 한국어 부처령 제249/2025/QĐ-BYT은 출생전 및 출생 후 선별검진이 권장되는 유전性疾病的翻译请稍等。-需要更多上下文以确保准确翻译，请提供完整句子或段落。中文《卫生部通知规定先天性疾病筛查目录》